PATHOBIOME TRANSFORMATION AND FEATURES OF ENTERAL INSUFFICIENCY IN PATIENTS WITH PERITONITIS DURING THE COVID-19 PANDEMIC

We studied the features of acute enteral failure in patients with peritonitis setting COVID-19 by studying properties pathobiome, biochemical, functional, pro-inflammatory and anti-apoptotic markers diffuse peritonitis. A retrospective randomized cohort controlled study was conducted; it included 84 divided into two groups. Stratified randomization used. The species composition luminal pathobiome were studied. 699 inoculations made, resulting 3024 isolates. morphofunctional coefficient, level alkaline phosphatase its intestinal isoform dynamically In immunohistochemical studies, we expression CD-3 Bcl-2. Patients addition to a decrease saprophytic microflora, showed significant increase Klebsiella spp., Candida, Clostridium spp. Citrobacter (p≤0.05). rate antibiotic resistance comparison group 8.3%, main - 36.9%. MRSA pathogens noted 86.4% cases, VRSA strains found 20.6% cases. had deficiency phosphatase, which persisted even on day 5 treatment. Macro- microscopic studies pronounced inflammatory apoptotic changes wall group. specific that is multiresistant antibiotics, wall, predisposition perforation small intestine are characteristics COVID-19.